CKD-EPI 2021

Adult2021Recommended

Latest race-free equation recommended by major nephrology organizations

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Calculate CKD-EPI 2021

Enter the values required by this equation to estimate the result.

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For educational and clinical reference use. Interpret results in clinical context.

Formula

eGFR=142×min⁡(Scr/κ,1)α×max⁡(Scr/κ,1)−1.200×0.9938age×sex factor\text{eGFR} = 142 \times \min(S_{cr}/\kappa, 1)^{\alpha} \times \max(S_{cr}/\kappa, 1)^{-1.200} \times 0.9938^{\text{age}} \times \text{sex factor}

Formula constants

SymbolDescriptionValue
142Base coefficient
κ\kappaSex-dependent creatinine coefficient
Female:0.7mg/dL
Male:0.9mg/dL
α\alphaExponent when SCr/κ < 1
Female:−0.241
Male:−0.302
−1.200Exponent when SCr/κ ≥ 1
0.9938Age decay factor (base for age exponent)per year
Sex factorSex-dependent multiplier
Female:1.012
Male:1.000
ScrS_{cr}inputSerum creatininemg/dL
AgeinputPatient ageyears

Required inputs

AgeSexCreatinine

Validated age range

18 to 120 years

Limitations

  • Less accurate in pregnancy
  • Less accurate with extremes of muscle mass
  • May be less accurate in certain ethnic populations

Clinical notes

  • Race-free equation developed in 2021
  • Recommended by KDIGO 2024 guidelines
  • Most accurate for adults ≥18 years
  • Less accurate in pregnancy, extremes of muscle mass
  • Gold standard for clinical practice
  • Validated in diverse populations

References

  • [1]Inker LA, Eneanya ND, Coresh J, et al. New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med. 2021;385(19):1737-1749. doi:10.1056/NEJMoa2102953
  • [2]KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S):S117-S314. doi:10.1016/j.kint.2023.10.018
  • [3]Delgado C, Baweja M, Crews DC, et al. A unifying approach for GFR estimation: recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease. Am J Kidney Dis. 2022;79(2):268-288. doi:10.1053/j.ajkd.2021.08.003

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