EKFC (European Kidney Function Consortium, 2021)
Adult2021Recommended
European-developed equation with improved accuracy across full age spectrum
Calculate EKFC
Enter the values required by this equation to estimate the result.
Enter all required values to see the result.
For educational and clinical reference use. Interpret results in clinical context.
Formula
Formula constants
| Symbol | Description | Value |
|---|---|---|
107.3 | Base coefficient | |
| Median serum creatinine reference (adults) | Female (≥18 y):0.70mg/dL Male (≥18 y):0.90mg/dL <18 y:Age-dependent (see Pottel et al.)mg/dL | |
| Exponent (depends on SCr/Q ratio) | SCr/Q < 1:−0.322 SCr/Q ≥ 1:−1.132 | |
Age factor | Age correction applied only when age > 40 | Age ≤ 40:1 (no correction) Age > 40:0.990^(age − 40) |
| input | Serum creatinine | mg/dL |
Ageinput | Patient age | years |
Required inputs
AgeSexCreatinine
Validated age range
2 to 120 years
Limitations
- Validated primarily in White European populations
- No Black patients included in original validation
- Q values may need adjustment for different populations
- Limited validation in Asian populations
Clinical notes
- Race-free equation developed by European Kidney Function Consortium
- Full age spectrum equation (2-120 years)
- Better continuity at pediatric-adult transition than CKD-EPI
- Uses median creatinine (Q) values for normalization
- Validated primarily in European populations
- Less overestimation in young adults compared to CKD-EPI
References
- [1]Pottel H, Björk J, Courbebaisse M, et al. Development and validation of a modified full age spectrum creatinine-based equation to estimate glomerular filtration rate. Ann Intern Med. 2021;174(2):183-191. doi:10.7326/M20-4366
- [2]Delanaye P, Cavalier E, Pottel H, Stehlé T. New and old GFR equations: a European perspective. Clin Kidney J. 2023;16(9):1375-1383. doi:10.1093/ckj/sfad039