CKiD U25 Creatinine

Pediatric2021Recommended

Age 1-25 years creatinine-based equation

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Calculate CKiD U25 Cr

Enter the values required by this equation to estimate the result.

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For educational and clinical reference use. Interpret results in clinical context.

Formula

eGFR=κ×heightScr where κ varies by sex and age\text{eGFR} = \kappa \times \frac{\text{height}}{S_{cr}} \text{ where } \kappa \text{ varies by sex and age}

Formula constants

SymbolDescriptionValue
κ\kappaAge- and sex-dependent coefficient (Female)
Age 1 to <12:36.1 × 1.008^(age − 12)
Age 12 to <18:36.1 × 1.023^(age − 12)
Age 18–25:41.4
κ\kappaAge- and sex-dependent coefficient (Male)
Age 1 to <12:39.0 × 1.008^(age − 12)
Age 12 to <18:39.0 × 1.045^(age − 12)
Age 18–25:50.8
HeightinputPatient heightmeters
ScrS_{cr}inputSerum creatininemg/dL

Required inputs

AgeSexHeightCreatinine

Validated age range

1 to 25 years

Limitations

  • Designed for mild-to-moderate CKD populations
  • May not be appropriate for screening asymptomatic patients
  • Requires accurate height measurement

Clinical notes

  • For individuals ages 1 to 25 with mild-to-moderate CKD
  • Superior estimation across pediatric and young adult age spectrum
  • No race-based modifiers required
  • Prevents 'jumps' in eGFR when transitioning from pediatric to adult equations

References

  • [1]Pierce CB, Muñoz A, Ng DK, Warady BA, Furth SL, Schwartz GJ. Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Kidney Int. 2021;99(4):948-956. doi:10.1016/j.kint.2020.10.047
  • [2]Ng DK, Pierce CB. Kidney disease progression in children and young adults with pediatric CKD: Epidemiologic perspectives and clinical applications. Semin Nephrol. 2021;41(5):405-415. doi:10.1016/j.semnephrol.2021.09.002

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