MDRD 4-Variable (IDMS)

Adult2006

MDRD equation using IDMS-standardized creatinine

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Calculate MDRD-4 (IDMS)

Enter the values required by this equation to estimate the result.

Enter all required values to see the result.

For educational and clinical reference use. Interpret results in clinical context.

Formula

eGFR=175×Scr−1.154×age−0.203×(0.742 if female)×(1.212 if Black)\text{eGFR} = 175 \times S_{cr}^{-1.154} \times \text{age}^{-0.203} \times (0.742 \text{ if female}) \times (1.212 \text{ if Black})

Formula constants

SymbolDescriptionValue
175Base coefficient (IDMS-standardized)
−1.154Creatinine exponent
−0.203Age exponent
Sex factorSex-dependent multiplier
Female:0.742
Male:1.000
Race factorRace-dependent multiplier
Black:1.212
Other:1.000
ScrS_{cr}inputSerum creatinine (IDMS-standardized)mg/dL
AgeinputPatient ageyears

Required inputs

AgeSexCreatinine
Optional:Race

Limitations

  • Less accurate than newer equations
  • Overestimates eGFR at higher levels
  • Based on CKD patient population
  • Superseded by CKD-EPI equations

Clinical notes

  • MDRD equation with IDMS-standardized creatinine
  • Historical equation, largely replaced by CKD-EPI 2021
  • Less accurate than CKD-EPI, especially at higher eGFR levels
  • May still be used in some laboratories
  • Includes race coefficient (controversial)
  • Consider CKD-EPI 2021 for current clinical practice

References

  • [1]Levey AS, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145(4):247-54. doi:10.7326/0003-4819-145-4-200608150-00004

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