Cockcroft-Gault

Adult1976

Estimates creatinine clearance, useful for drug dosing

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Calculate C-G

Enter the values required by this equation to estimate the result.

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For educational and clinical reference use. Interpret results in clinical context.

Formula

CrCl=(140−age)×weight×(0.85 if female)72×Scr\text{CrCl} = \frac{(140 - \text{age}) \times \text{weight} \times (0.85 \text{ if female})}{72 \times S_{cr}}

Formula constants

SymbolDescriptionValue
140Age subtraction constantyears
72Denominator constant
Sex factorSex-dependent multiplier
Female:0.85
Male:1.00
WeightinputActual body weightkg
ScrS_{cr}inputSerum creatininemg/dL
AgeinputPatient ageyears

Required inputs

AgeSexCreatinineWeight

Limitations

  • Not standardized to body surface area
  • Less accurate than modern eGFR equations
  • May be inaccurate in obese or elderly patients
  • Estimates clearance, not filtration rate

Clinical notes

  • Estimates creatinine clearance, not eGFR
  • Commonly used for drug dosing calculations
  • Requires patient weight
  • Not adjusted for body surface area
  • May overestimate clearance in obese patients

References

  • [1]Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. doi:10.1159/000180580

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